PRE-CANCEROUS POLYPS

Colonic Polypectomy

  • Most colorectal cancers develop through a gradual sequence of polyp growth
  • Colorectal cancer mortality can be significantly reduced by colonoscopy and colonic polypectomy
  • 19 million colonoscopies are performed in the US each year
  • Expected incidence of pre-malignant polypoid lesions is around 30%
  • 5 % of colonic polyps are laterally spreading lesions (LSLs)
  • LSLs larger then 20mm are considered high risk precursors of CRC
  • 5 million polyps are discovered each year, in the US, of which around 300,000 are LSLs

Current Practice

  • LSLs are diagnosed during routine screening or surveillance colonoscopies
  • In most cases patient is referred to an expert endoscopists for removal of LSLs
  • Selection of removal technique requires lesions to be categorized based on location, size, morphology, pit pattern and vascular pattern
  • Endoscopic Mucosal Resection (EMR), Endoscopic Submucosal Dissection (ESD) and Surgical Therapy are some of the available treatment options for polypectomy
  • LSL removal is technically demanding, requires highly trained personal and specialized equipment
  • Operating time can range from 2-5 hours for removal of a single LSL

PLP-33 Formulation

  • A Novel formula for treatment of LSL Polyps: 'pre' and 'post' polypectomy
  • Formula demonstrated significant synergistic antitumor effect in pre clinical studies
  • Preclinical POC validation
  • Upcoming in-vivo studies
  • Dossier preparation for submission of Pre-IND meeting request with FDA